🧬 Unraveling Cancer Biology through Single-Cell & Spatial Transcriptomics | Focused on Biological Insights from Multi-Omics Data

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πŸ“Seoul, Korea
Harim Chun

About

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Published Papers
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Conference Presentations
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Teaching Experience
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Awards

I am a Ph.D. student in Biomedical Sciences at The Catholic University of Korea, specializing in cancer genomics, single-cell genomics, and bioinformatics. My research focuses on understanding the genetic underpinnings of cancer and developing computational tools for complex biological data analysis.

With a strong background in multi-omics data integration and machine learning approaches, I aim to contribute to precision oncology and personalized therapeutic strategies.

Education

Ph.D. in Biomedical Sciences

The Catholic University of Korea College of Medicine

Seoul, Korea

Mar 2025 – Present

Ph.D. candidate

M.S. in Biomedical Sciences

Korea University College of Medicine

Seoul, Korea

Mar 2021 – Aug 2024

Thesis: Identification of molecular biomarkers of response to immune checkpoint inhibitors

Exchange Student, Biology

University of Mississippi

University, Mississippi, USA

Jan 2019 – May 2019

Exchange Student Program

B.S. in School of Systems Biomedical Science (Bioengineering and Bioinformatics)

Soongsil University

Seoul, Korea

Interdisciplinary Major in Big Data Computing

Mar 2015 – Feb 2021

Research Areas

🧬

Cancer Genomics

Investigating genetic mechanisms driving oncogenesis and immunotherapy response.

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Single-Cell Genomics

Uncovering cellular heterogeneity via scRNA-seq to identify rare populations.

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Multi-Omics

Integrating genomics, transcriptomics, and epigenomics for system-level insights.

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Bioinformatics

Developing pipelines for NGS data analysis, variant calling, and network inference.

Skills

BWA-MEM, GATK, VEP, SnpEff, ANNOVAR, Hisat, Salmon, DESeq2, Limma, CIBERSORTx, Seurat, Harmony, Monocle3, MAST, miR-loR, WGCNA, SCENIC, Cytoscape, GSEA, IPA

with

Research Experience

PathFinderLab

Sep 2024 - Present

The Catholic University of Korea & Korea University Anam Hospital

Advisor: Sung Hak Lee, M.D., Ph.D.

Graduate Student (Mar. 2025 - )

Research Associate (Sep. 2024 – Feb. 2025)

Choi Lab (Human Genetics & Genomics)

Jul 2020 – Aug 2024

Korea University

Advisor: Jungmin Choi, Ph.D.

Graduate Student (Mar. 2021 - Aug. 2024)

Undergraduate Research Intern (Jul. 2020 - Feb. 2021)

Liver Cancer Biomarker Discovery

Identified pseudogene-derived lncRNA biomarkers in liver cancer using TCGA-LIHC dataset (369 tumor, 49 normal tissues). Discovered 465 differentially expressed pseudogenes and identified PLEKHA8P1 as a key biomarker.

Collaboration: Prof. Lark Kyun Kim (Yonsei University College of Medicine)

Metachronous Gastric Cancer

Analyzed RNA-seq data from 46 patients, identified 13 DEGs including KDF1 and CDK1 as significant biomarkers for metachronous gastric cancer progression.

Collaboration: Prof. Soo-jeong Cho (Seoul National University College of Medicine)

Hematopoietic Stem Cell Niche

Analyzed transcriptional heterogeneity in HPSC using scRNA-seq data from Cxcr4 cKO and control mice. Identified key regulators of HSC homeostasis.

Collaboration: Prof. Joao Pereira (Yale University)

Publications

Predictive biomarkers for metachronous gastric cancer development after endoscopic resection of early gastric cancer

Kim B*, Chun H*, Lee J, Park M, Kwak Y, Kim JM, Kim SG, Ryu JK, Choi J^, Cho SJ^

Cancer Medicine. 2024

* Co-first Author

Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size

Miao R, Chun H, Gomes A.C., Choi J, Pereira J

Nature Communications. 2022

PLEKHA8P1 Promotes Tumor Progression and Indicates Poor Prognosis of Liver Cancer

Lee J*, Hwang JH*, Chun H*, Woo W, Oh S, Choi J^, Kim LK^

Int. J. Mol. Sci. 2021, 22, 7614

* Co-first Author

Awards & Honors

Excellence Poster Award

The 20th KOGO Winter Symposium 2024

Brain Korea 21 (BK21) Scholarship

Korea Research Foundation 2021–2022

CoRE Tutoring Best Tutor Award

Soongsil University 2020

Semester Honor Scholarship

Soongsil University 2016, 2020

Teaching Experience

KSBI-BIML 2024

Feb 2024

Single-Cell Multiomics

Korea Society for Bioinformatics

Seoul, Korea

KSBI-BIML 2023

Feb 2023

Spatial Transcriptome with R

Korea Society for Bioinformatics

Seoul, Korea

KOGO Winter Workshop

Feb 2023

Spatial Transcriptome with R

Korea Genome Organization

Seoul, Korea

Digital Healthcare Professionals Training

Oct 2022

NGS Data Analysis Pipeline (GATK Workflow)

Korea University, INNOPOLIS

Seoul, Korea

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